You could run E15 with no problems, in fact most gas that is available in Wisconsin is E10.
If you put E85 in, it won’t do any damage to fuel filter/ lines/injection system, but it won’t run in our cars either.
E85 has about 30% less BTU’s of energy compared to the equal volume of regular gas. So in order to run it, you would need to provide 30% more fuel.
Flex-fuel cars have an additional sensor that detects the ratio of ethanol/gas, the ecu then uses this sensors data to determine the proper amount of extra fuel to add depending on the E value of the fuel in use.
As for running E85 in an engine designed to run on regular gas, it doesn’t make sense. In general E85 costs 80% of regular gas but only gets 70% the mpg.
IMHO…. The real benefit to E85 are it’s high octane levels and it’s use as a cheaper racing fuel than regular race gas.
With E85 you can run more boost with lower risk of knock or run an N/A engine with 14:1 compression.